Bis-tris methane

Names

[ Name ]:
Bis-tris methane

[Synonym ]:
2,2-Bis(hydroxymethyl)-2,2',2''-nitilotriethanol
Bis-tris methane
2-[Bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)-1,3-propanediol
2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)propane-1,3-diol
2-(Bis(2-hydroxyethyl)amino)-2-(hydroxymethyl)propane-1,3-diol
1,3-Propanediol, 2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)-
Bis-tris-d19
2,2-bis(hydroxymethyl)-2,2′,2″-nitrilotriethanol
2-[Bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)propan-1,3-diol
BIS-TRIS
Bis(2-hydroxyethyl)imino-tris(hydroxymethyl)propane
Bis(2-hydroxyethyl)amino-tris(hydroxymethyl)methane
2,2-Bis(hydroxymethyl)-2,2',2"-nitrilotriethanol

Biological Activity

[Description]:

Bis-Tris-d19 is the deuterium labeled Bis-Tris[1]. Bis-Tris is a commonly used buffer[2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

[2]. Oh, Soon Jin, et al. Structure and phosphodiesterase activity of Bis-Tris coordinated lanthanide(III) complexes.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
466.2±40.0 °C at 760 mmHg

[ Molecular Formula ]:
C₈H₁₉NO₅

[ Molecular Weight ]:
209.240

[ Flash Point ]:
288.0±26.0 °C

[ Exact Mass ]:
209.126328

[ PSA ]:
104.39000

[ LogP ]:
-0.67

[ Vapour Pressure ]:
0.0±2.6 mmHg at 25°C

[ Index of Refraction ]:
1.563

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ RIDADR ]:
NONH for all modes of transport