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Proteasome Substrate II

Names

[ CAS No. ]:
348086-66-8

[ Name ]:
Proteasome Substrate II

[Synonym ]:
Z-LEU-LEU-GLU-7-AMINO-4-METHYLCOUMARIN
Z-LLE-AMC
Z-ILE-AMC
N-[(Benzyloxy)carbonyl]-L-leucyl-L-leucyl-N-(4-methyl-2-oxo-2H-chromen-7-yl)-L-α-glutamine
Z-LEU-LEU-GLU-MCA
Cbz-Leu-Leu-Glu-AMC,Z-LLE-AMC
L-α-Glutamine, N-[(phenylmethoxy)carbonyl]-L-leucyl-L-leucyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-
Z-LEU-LEU-GLU-7-AMIDO-4-METHYLCOUMARIN

Biological Activity

[Description]:

Z-Leu-Leu-Glu-AMC is a substrate peptide, and can be used for determination of postacidic-like hydrolysing activity of 20S proteasome[1]

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Metabolic Enzyme/Protease >> Proteasome

[References]

[1]. McNaught KS, et al. Proteasomal function is impaired in substantia nigra in Parkinson's disease. Neurosci Lett. 2001 Jan 19;297(3):191-4.  

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
967.8±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C35H44N4O9

[ Molecular Weight ]:
664.745

[ Flash Point ]:
539.1±34.3 °C

[ Exact Mass ]:
664.310852

[ PSA ]:
193.14000

[ LogP ]:
5.74

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.578

Safety Information

[ Safety Phrases ]:
22-24/25

[ WGK Germany ]:
3

Related Compounds