CB1R antagonist 1

Names

[ CAS No. ]:
334668-69-8

[ Name ]:
CB1R antagonist 1

Biological Activity

[Description]:

CB1R Allosteric modulator 5, a novel1-sulfonyl-4-acylpiperazines as selective cannabinoid-1 receptor (CB1R) inverse agonist with an IC50 value of 4.2 μM and EC50 value of ＞10 μM. CB1R Allosteric modulator 5 can be used for the research of metabolic and obesity[1].

[Related Catalog]:

Research Areas >> Metabolic Disease
Signaling Pathways >> GPCR/G Protein >> Cannabinoid Receptor

[Target]

hCB1-R:4.2 μM (IC50)

hCB1-R:10 μM (EC50)


[In Vitro]

CB1R Allosteric modulator 5 has cannabinoid-1 receptor (CB1R) activity with an IC50value of 4.2 μM and EC50 value of ＞10 μM[1].

[References]

[1]. Petr Vachal, et al. 1-Sulfonyl-4-acylpiperazines as selective cannabinoid-1 receptor (CB1R) inverse agonists for the treatment of obesity. J Med Chem. 2009 Apr 23;52(8):2550-8

Chemical & Physical Properties

[ Molecular Formula ]:
C18H23F3N2O3S

[ Molecular Weight ]:
404.45

Related Compounds