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squalamine lactate

Names

[ CAS No. ]:
320725-47-1

[ Name ]:
squalamine lactate

[Synonym ]:
(2S)-2-Hydroxypropanoic acid - (3β,5α,7α,24R)-3-({3-[(4-aminobutyl)amino]propyl}amino)-7-hydroxycholestan-24-yl hydrogen sulfate hydrate (1:1:1)
squalamine lactate

Biological Activity

[Description]:

Squalamine lactate is an aminosterol compound discovered in the tissues of the dogfish shark, with antimicrobial activity, and used for the treatment of neovascular age-related macular degeneration.

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Bacterial
Natural Products >> Others
Research Areas >> Cardiovascular Disease
Research Areas >> Infection

[In Vitro]

Squalamine lactate has a more generalized effect on the cellular signaling cascade that is common to both VEGF and other growth factors[1]. Squalamine blocks the action of VEGF and integrin expression, thereby inhibiting angiogenesis, when bound to calmodulin[2].

[In Vivo]

Squalamine is ineffective when administered intravitreally and therefore requires intravenous dosing. However, systemic dosing has yielded promising results in rats as well as humans[2].

[References]

[1]. Hussain RM, et al. Emerging vascular endothelial growth factor antagonists to treat neovascular age-related macular degeneration. Expert Opin Emerg Drugs. 2017 Sep;22(3):235-246.

[2]. Emerson MV, et al. Current and emerging therapies for the treatment of age-related macular degeneration. Clin Ophthalmol. 2008 Jun;2(2):377-88.


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Chemical & Physical Properties

[ Molecular Formula ]:
C37H71N3O8S

[ Molecular Weight ]:
736.055

[ Exact Mass ]:
735.506775

[ Storage condition ]:
-20°C

Related Compounds