L-Arg(Me, Me)-OH (asymmetrical)

Names

[ Name ]:
L-Arg(Me, Me)-OH (asymmetrical)

[Synonym ]:
N(omega),N(omega)-dimethyl-L-arginine
N,N-Dimethylarginine
2-AMINO-5-(3,3-DIMETHYLGUANIDINO)PENTANOIC ACID
NG,NG-dimethyl-L-arginine
L-ORNITHINE,N5-[(DIMETHYLAMINO)IMINOMETHYL]-
asymmetric NG,NG-dimethyl-L-arginine
N-Hydroxyoxalyl-anthranilsaeure
NG,NG-dimethylarginine
L-Arg(Me, Me)-OH (asymmetrical)
(2S)-2-Amino-5-[(Amino-Dimethylaminomethylidene)Amino]Pentanoic Acid

Biological Activity

[Description]:

Asymmetric dimethylarginine is an endogenous inhibitor of nitric oxide synthase (NOS), and functions as a marker of endothelial dysfunction in a number of pathological states.

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> NO Synthase

Research Areas >> Cardiovascular Disease

Natural Products >> Others

[Target]

Human Endogenous Metabolite

[In Vitro]

Asymmetric dimethylarginine is an endogenous inhibitor of nitric oxide synthase (NOS), and functions as a marker of endothelial dysfunction in a number of pathological states. Asymmetric dimethylarginine (ADMA) is elevated in HIV-1 infection[1].

[References]

[1]. Hudson CL, et al. The cardiovascular risk marker asymmetric dimethylarginine is elevated in asymptomatic, untreated HIV-1 infection and correlates with markers of immune activation and disease progression. Ann Clin Biochem. 2014 Sep;51(Pt 5):568-75.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.239g/cm3

[ Boiling Point ]:
372.555°C at 760 mmHg

[ Molecular Formula ]:
C₈H₁₈N₄O₂

[ Molecular Weight ]:
202.25400

[ Flash Point ]:
179.115°C

[ Exact Mass ]:
202.14300

[ PSA ]:
102.44000

[ LogP ]:
0.45540

Safety Information

[ HS Code ]:
2925290090

Customs

[ HS Code ]: 2925290090

[ Summary ]:
2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%