(+)-Nicotine
Names
[ CAS No. ]:
25162-00-9
[ Name ]:
(+)-Nicotine
[Synonym ]:
Leukotriene B4 Lipid Maps MS Standard
leukotriene B4 ethanol solution
R-(+)-Nicotine
Leukotriene B4
6Z,8E,10E,14Z,5S,12R-diHETE
LTB4
Chemical & Physical Properties
[ Density]:
1.032g/cm3
[ Boiling Point ]:
244.4ºC at 760mmHg
[ Molecular Formula ]:
C10H14N2
[ Molecular Weight ]:
162.23200
[ Flash Point ]:
101.7ºC
[ Exact Mass ]:
162.11600
[ PSA ]:
16.13000
[ LogP ]:
1.78620
[ Storage condition ]:
-20°C
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- QS5260000
- CHEMICAL NAME :
- 2'-beta-H-Nicotine
- CAS REGISTRY NUMBER :
- 25162-00-9
- BEILSTEIN REFERENCE NO. :
- 4666243
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C10-H14-N2
- MOLECULAR WEIGHT :
- 162.26
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 50 mg/kg
- TOXIC EFFECTS :
- Cardiac - pulse rate Vascular - BP elevation not characterized in autonomic section
- REFERENCE :
- 85IXA4 "Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948 Volume(issue)/page/year: -,584,1948
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 6150 ug/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 84,1,1984
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Amphibian - frog
- DOSE/DURATION :
- 40 mg/kg
- TOXIC EFFECTS :
- Cardiac - pulse rate Vascular - BP elevation not characterized in autonomic section
- REFERENCE :
- 85IXA4 "Structure et Activite Pharmacodyanmique des Medicaments du Systeme Nerveux Vegetatif," Bovet, D., and F. Bovet-Nitti, New York, S. Karger, 1948 Volume(issue)/page/year: -,584,1948
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Bird - domestic
- DOSE/DURATION :
- 25 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PHZOA9 Physiological Zoology. (Univ. of Chicago Press, Journals Div., POB 37005, Chicago, IL 60637) V.1- 1928- Volume(issue)/page/year: 12,238,1939
Safety Information
[ Hazard Codes ]:
Xi
[ HS Code ]:
2933990090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2933990090
[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%