PIM1-IN-7

Names

[ CAS No. ]:
2439168-72-4

[ Name ]:
PIM1-IN-7

Biological Activity

[Description]:

PIM1-IN-7 (compound 6c) is a potent PIM-1 inhibitor, with an IC50 of 0.67 μM. PIM1-IN-7 shows the high cytotoxicity activity against HCT-116 and MCF-7 cells, with IC50 values of 42.9 and 7.68 μM, respectively[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> JAK/STAT Signaling >> Pim

[Target]

PIM1:0.67 μM (IC50)


[References]

[1]. Philoppes JN, et al. New pyrazolopyrimidine derivatives with anticancer activity: Design, synthesis, PIM-1 inhibition, molecular docking study and molecular dynamics. Bioorg Chem. 2020 Jul;100:103944.

Chemical & Physical Properties

[ Molecular Formula ]:
C23H23N5O

[ Molecular Weight ]:
385.46

Related Compounds