PIM1-IN-6

Names

[ CAS No. ]:
2439168-69-9

[ Name ]:
PIM1-IN-6

Biological Activity

[Description]:

PIM1-IN-6 (compound 5h) is a potent PIM-1 inhibitor, with an IC50 of 0.60 μM. PIM1-IN-6 shows the high cytotoxicity activity against HCT-116 and MCF-7 cells, with IC50 values of 1.51 and 15.2 μM, respectively[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> JAK/STAT Signaling >> Pim

[Target]

PIM1:0.60 μM (IC50)


[References]

[1]. Philoppes JN, et al. New pyrazolopyrimidine derivatives with anticancer activity: Design, synthesis, PIM-1 inhibition, molecular docking study and molecular dynamics. Bioorg Chem. 2020 Jul;100:103944.

Chemical & Physical Properties

[ Molecular Formula ]:
C21H18N6O4

[ Molecular Weight ]:
418.41

Related Compounds