DDR1-IN-5

Names

[ CAS No. ]:
2416022-90-5

[ Name ]:
DDR1-IN-5

Biological Activity

[Description]:

DDR1-IN-5 is a selective Discoidin Domain Receptor family, member 1 (DDR1) inhibitor with an IC50 of 7.36 nM. DDR1-IN-5 inhibits auto-phosphorylation DDR1b (Y513) with an IC50 of 4.1 nM. DDR1-IN-5 has anti-cancer activity[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Discoidin Domain Receptor

[Target]

DDR1:7.36 nM (IC50)


[In Vitro]

DDR1-IN-5 (compound 121; for 24 hours) inhibits collagen production in human hepatic stellate cell LX-2 (IC50=62 nM)[1]. DDR1-IN-5 (72 hours) has cytotoxicity in LX-2 cells (CC50>40 μM)[1].

[References]

[1]. Aleksandr M. Aliper, et al. Kinase inhibitors. WO2020079652A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C22H13F3N6O

[ Molecular Weight ]:
434.37

Related Compounds