2416022-90-5
2416022-90-5 structure
- Name: DDR1-IN-5
- Chemical Name: DDR1-IN-5
- CAS Number: 2416022-90-5
- Molecular Formula: C22H13F3N6O
- Molecular Weight: 434.37
- Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK Discoidin Domain Receptor
- Create Date: 2020-08-08 17:00:19
- Modify Date: 2024-01-10 18:45:59
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DDR1-IN-5 is a selective Discoidin Domain Receptor family, member 1 (DDR1) inhibitor with an IC50 of 7.36 nM. DDR1-IN-5 inhibits auto-phosphorylation DDR1b (Y513) with an IC50 of 4.1 nM. DDR1-IN-5 has anti-cancer activity[1].
| Name | DDR1-IN-5 |
|---|
| Description | DDR1-IN-5 is a selective Discoidin Domain Receptor family, member 1 (DDR1) inhibitor with an IC50 of 7.36 nM. DDR1-IN-5 inhibits auto-phosphorylation DDR1b (Y513) with an IC50 of 4.1 nM. DDR1-IN-5 has anti-cancer activity[1]. |
|---|---|
| Related Catalog | |
| Target |
DDR1:7.36 nM (IC50) |
| In Vitro | DDR1-IN-5 (compound 121; for 24 hours) inhibits collagen production in human hepatic stellate cell LX-2 (IC50=62 nM)[1]. DDR1-IN-5 (72 hours) has cytotoxicity in LX-2 cells (CC50>40 μM)[1]. |
| References |
[1]. Aleksandr M. Aliper, et al. Kinase inhibitors. WO2020079652A1. |
| Molecular Formula | C22H13F3N6O |
|---|---|
| Molecular Weight | 434.37 |