CBP/p300-IN-15

Names

[ CAS No. ]:
2379409-91-1

[ Name ]:
CBP/p300-IN-15

Biological Activity

[Description]:

CBP/p300-IN-15 (compound 13a) is a potent p300/CBP inhibitor, with IC50 values of 2.50 and 28.0 nM, respectively. CBP/p300-IN-15 shows good activity against OVCAR-3 and A2780 cell line, with EC50 values of 0.865 and 2.71 μM, respectively. CBP/p300-IN-15 can be used for ovarian cancer research[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Epigenetics >> Histone Acetyltransferase
Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain

[Target]

CBP:28.0 nM (IC50)

p300:2.50 nM (IC50)


[References]

[1]. Ding H, et al. Design, synthesis and biological evaluation of a novel spiro oxazolidinedione as potent p300/CBP HAT inhibitor for the treatment of ovarian cancer. Bioorg Med Chem. 2021 Dec 15;52:116512.

Chemical & Physical Properties

[ Molecular Formula ]:
C26H28N4O5

[ Molecular Weight ]:
476.52

Related Compounds