2379409-91-1

2379409-91-1 structure

Name: CBP/p300-IN-15
Chemical Name: CBP/p300-IN-15
CAS Number: 2379409-91-1
Molecular Formula: C₂₆H₂₈N₄O₅
Molecular Weight: 476.52
Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
Create Date: 2022-08-22 22:59:32
Modify Date: 2023-05-20 12:36:10
CBP/p300-IN-15 (compound 13a) is a potent p300/CBP inhibitor, with IC50 values of 2.50 and 28.0 nM, respectively. CBP/p300-IN-15 shows good activity against OVCAR-3 and A2780 cell line, with EC50 values of 0.865 and 2.71 μM, respectively. CBP/p300-IN-15 can be used for ovarian cancer research[1].

Name	CBP/p300-IN-15

Description	CBP/p300-IN-15 (compound 13a) is a potent p300/CBP inhibitor, with IC50 values of 2.50 and 28.0 nM, respectively. CBP/p300-IN-15 shows good activity against OVCAR-3 and A2780 cell line, with EC50 values of 0.865 and 2.71 μM, respectively. CBP/p300-IN-15 can be used for ovarian cancer research[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Histone Acetyltransferase Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain
Target	CBP:28.0 nM (IC50) p300:2.50 nM (IC50)
References	[1]. Ding H, et al. Design, synthesis and biological evaluation of a novel spiro oxazolidinedione as potent p300/CBP HAT inhibitor for the treatment of ovarian cancer. Bioorg Med Chem. 2021 Dec 15;52:116512.

Molecular Formula	C₂₆H₂₈N₄O₅
Molecular Weight	476.52