KRAS G12C inhibitor 17

Names

[ Name ]:
KRAS G12C inhibitor 17

Biological Activity

[Description]:

KRAS G12C inhibitor 17 is a potent KRAS G12C inhibitor extracted from patent WO2019110751A1, compound 82, has an IC50 of 5 nM[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> GPCR/G Protein >> Ras

[Target]

KRas G12C:5 nM (IC50)

[References]

[1]. Jason Grant Kettle, et al. Tetracyclic compounds as inhibitors of g12c mutant ras protein, for use as anti-cancer agents. WO2019110751A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₂₀ClF₂N₃O₃

[ Molecular Weight ]:
471.88

Related Compounds

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