IU1-248

Names

[ CAS No. ]:
2307472-03-1

[ Name ]:
IU1-248

Biological Activity

[Description]:

IU1-248, a derivative of IU1, is a potent and selective USP14 inhibitor with an IC50 of 0.83 μM.

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Deubiquitinase

[In Vitro]

IU1-248 exhibits an IC50 value of 0.83 μM toward USP14, which is comparable to that of IU1-47 (IC50=0.68 μM) and 10-fold more potent than that of IU1 (IC50=12.25 μM)[1].

[References]

[1]. Yiwei Wang, et al. Small molecule inhibitors reveal allosteric regulation of USP14 via steric blockade. Cell Res. 2018 Dec;28(12):1186-1194.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₂₃N₃O₂

[ Molecular Weight ]:
337.42

[ Storage condition ]:
2-8°C

IU1-248

Names

Biological Activity

Chemical & Physical Properties

Related Compounds