Hydroxocobalamin Acetate

Names

[ Name ]:
Hydroxocobalamin Acetate

[Synonym ]:
Hydroxocobalamin acetate
Vitamin B12a acetate
HYDROXOCOBALAMIN ACETATE

Biological Activity

[Description]:

Hydroxocobalamin acetate is an injectable naturally occurring form of vitamin B12 with a favorable adverse effect profile, used as a dietary supplement in the treatment of vitamin B12 deficiency including pernicious anemia[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Metabolic Disease

[Target]

The cobalt atom of hydroxocobalamin binds cyanide and nitric oxide (NO) and hydroxocobalamin attenuates vascular responses to NO in vitro[3].

[References]

[1]. Cheungpasitporn W, et al. High-dose hydroxocobalamin for vasoplegic syndrome causing false blood leak alarm. Clin Kidney J. 2017 Jun;10(3):357-362.

[2]. Wang H, et al. Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency. Cochrane Database Syst Rev. 2018 Mar 15;3:CD004655.

[3]. Greenberg SS, et al. Hydroxocobalamin (vitamin B12a) prevents and reverses endotoxin-induced hypotension and mortality in rodents: role of nitric oxide. J Pharmacol Exp Ther. 1995 Apr;273(1):257-65.

Chemical & Physical Properties

[ Melting Point ]:
>300ºC.

[ Molecular Formula ]:
C₆₄H₉₁CoN₁₃O₁₆P

[ Molecular Weight ]:
1388.39000

[ Exact Mass ]:
1387.58000

[ PSA ]:
490.17000

[ LogP ]:
6.62930

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GG3740000

CHEMICAL NAME :: Cobinamide, acetate (salt) hydroxide, dihydrogen phosphate (ester), inner salt, 3'-ester with 5,6-dimethyl-1-alpha-D-ribofuranosylbenzimidazole

CAS REGISTRY NUMBER :: 22465-48-1

LAST UPDATED :: 199409

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C64-H91-Co-N13-O16-P

MOLECULAR WEIGHT :: 1388.58

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,622,1982

Safety Information

[ Symbol ]:

GHS08

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H351

[ Precautionary Statements ]:
P280

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
GG3740000

Articles

Processing of alkylcobalamins in mammalian cells: A role for the MMACHC (cblC) gene product.

Mol. Genet. Metab. 97 , 260-266, (2009)

The MMACHC gene product of the cblC complementation group, referred to as the cblC protein, catalyzes the in vitro and in vivo decyanation of cyanocobalamin (vitamin B(12)). We hypothesized that the c...

Vitamin B12-derivatives-enzyme cofactors and ligands of proteins and nucleic acids.

Chem. Soc. Rev. 40 , 4346-4363, (2011)

B(12)-cofactors play important roles in the metabolism of microorganisms, animals and humans. Microorganisms are the only natural sources of B(12)-derivatives, and the latter are "vitamins" for other ...

B12 trafficking in mammals: A for coenzyme escort service.

ACS Chem. Biol. 1 , 149-159, (2006)

Many coenzymes are vitamins that are assimilated in mammals into their active form from precursors obtained from the diet. They are often both rare and reactive rendering the likelihood low that the c...

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.