Sirt2-IN-6

Names

[ CAS No. ]:
2243151-81-5

[ Name ]:
Sirt2-IN-6

Biological Activity

[Description]:

Sirt2-IN-6 (compound 24a) potent and selective inhibitor of SIRT2, with an IC50 of 0.815 μM. Sirt2-IN-6 can be used for the research of cancer[1].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> Sirtuin
Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Sirtuin

[Target]

SIRT2:0.815 μM (IC50)


[References]

[1]. Yang LL, et, al. X-ray crystal structure guided discovery of new selective, substrate-mimicking sirtuin 2 inhibitors that exhibit activities against non-small cell lung cancer cells. Eur J Med Chem. 2018 Jul 15;155:806-823.

Chemical & Physical Properties

[ Molecular Formula ]:
C26H26N6O3S

[ Molecular Weight ]:
502.59

Related Compounds