SIRT2-IN-10

SIRT2-IN-10 (Compound 12) is a potent SIRT2 inhibitor with an IC50 of 1.3 μM. SIRT2-IN-10 can be used for the research of cancer and neurodegenerative disease[1].

Signaling Pathways >> Epigenetics >> Sirtuin

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Sirtuin

Research Areas >> Neurological Disease

SIRT2[1]

SIRT2-IN-10 (Compound 12) (0-50 μM; 72 h) inhibits the proliferation of MCF-7 cells in a concentration-dependent manner[1]. SIRT2-IN-10 (6.25-50 μM; 6 h) increased the acetylation level of α-tubulin in a concentration-dependent manner in MCF-7 cells[1]. Cell Proliferation Assay[1] Cell Line: MCF-7 cells Concentration: 0, 0.6, 1.8, 5.5, 16.6 and 50.0 μM Incubation Time: 72 h Result: Inhibited the proliferation in a concentration-dependent manner. Western Blot Analysis[1] Cell Line: MCF-7 cells Concentration: 6.25, 12.5, 25 and 50 μM Incubation Time: 6 h Result: Dose-dependently increased the acetylation level of α-tubulin.

[1]. Shengyong Yang, et al. The purposes of 5H- [1,2,4] triazine [5,6-b] indole derivatives of 3 substitutions. Patent CN108309982A.