DDC-01-163
Names
[ CAS No. ]:
2140806-84-2
[ Name ]:
DDC-01-163
Biological Activity
[Description]:
DDC-01-163 is an allosteric EGFR degrader that selectively inhibit the proliferation of L858R/T790M (L/T) mutant Ba/F3 cells while leaving wildtype EGFR Ba/F3 cells unaffected;DDC-01-163 exhibited an acceptable biochemical potency with an IC50 value of 45 nM against EGFR L858R/T790M.DDC-01-163 is also effective against osimertinib-resistant cells with L/T/C797S and L/T/L718Q EGFR mutations.The anti-proliferative activity of DDC-01-163 against L858R/T790M EGFR-Ba/F3 cells is enhanced when combined with an ATP-site EGFR inhibitor, Osimertinib.
[References]
1. Jaebong Jang, et al. Angew Chem Int Ed Engl. 2020 Aug 17;59(34):14481-14489.
Chemical & Physical Properties
[ Molecular Formula ]:
C49H51N9O9S
[ Molecular Weight ]:
942.061
Related Compounds
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