CCC07-01

CCC07-01 (CCC 0701) is a novel alkylating compound that is capable of disrupting expression of PD-1, PD-L1 and CTLA-4 genes with IC50 of 15, 10 and 5 nM in cell-base assays; significantly suppresses PD-1, PD-L1 and CTLA-4 mRNA levels in several cell lines, CCC07-01 is sufficiently lipophilic that enhaced the inhibitory effect of CD94-NKG-2A receptor expressed on subsets of NK cells γδ and CD8+ T cells.

References 1. US Patent WO 2018056361. 2. Horiki Nagase, et al. 2018 AACR #2711: Development of a new innovative multifunctional immune checkpoint inhibitor. View Related Products by Target PD-1/PD-L1