LY-411575
Names
[ CAS No. ]:
209984-57-6
[ Name ]:
LY-411575
[Synonym ]:
N2-((2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl)-N1-((7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo(b,d)azepin-7-yl)-L-alaninamide
Benzeneacetamide, N-[(1S)-2-[[(7S)-6,7-dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-α-hydroxy-, (αS)-
N-[(2S)-2-(3,5-Difluorophenyl)-2-hydroxyacetyl]-N-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide
(2S)-2-[[(2S)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]amino]-N-[(7S)-5-methyl-6-oxo-7H-benzo[d][1]benzazepin-7-yl]propanamide
cc-581
LY411575
Biological Activity
[Description]:
[Related Catalog]:
[Target]
IC50: 0.078 nM (γ-secretase in membrane), 0.082 nM (γ-secretase cell-based), 0.39 nM (Notch S3 cleavage cell-based)[1]
[In Vitro]
[In Vivo]
[Animal admin]
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Density]:
1.4±0.1 g/cm3
[ Boiling Point ]:
836.0±65.0 °C at 760 mmHg
[ Melting Point ]:
328.47°C
[ Molecular Formula ]:
C26H23F2N3O4
[ Molecular Weight ]:
479.475
[ Flash Point ]:
459.4±34.3 °C
[ Exact Mass ]:
479.165649
[ PSA ]:
98.74000
[ LogP ]:
4.75
[ Appearance of Characters ]:
white to beige
[ Vapour Pressure ]:
0.0±3.2 mmHg at 25°C
[ Index of Refraction ]:
1.652
[ Storage condition ]:
?20°C
[ Water Solubility ]:
DMSO: soluble5mg/mL, clear
MSDS
Safety Information
[ Safety Phrases ]:
24/25
[ RIDADR ]:
NONH for all modes of transport
[ HS Code ]:
29337900
Articles
Br. J. Cancer 105 , 796-806, (2011)
We reported that Notch-1, a potent breast oncogene, is activated in response to trastuzumab and contributes to trastuzumab resistance in vitro. We sought to determine the preclinical benefit of combin...