Crenigacestat(LY3039478)

Names

[ Name ]:
Crenigacestat(LY3039478)

[Synonym ]:
4-trifluoro-N-((S)-1-(((S)-5-(2-hydroxyethyl)-6-oxo-6
3-b]azepin-7-yl)amino)-1-oxopropan-2-yl)butanamide
4,4,4-Trifluoro-N-[(2S)-1-{[(7S)-5-(2-hydroxyethyl)-6-oxo-6,7-dihydro-5H-pyrido[3,2-a][3]benzazepin-7-yl]amino}-1-oxo-2-propanyl]butanamide
Butanamide, N-[(1S)-2-[[(7S)-6,7-dihydro-5-(2-hydroxyethyl)-6-oxo-5H-pyrido[3,2-a][3]benzazepin-7-yl]amino]-1-methyl-2-oxoethyl]-4,4,4-trifluoro-
UNII:923X28214S
Crenigacestat
LY3039478
LY-3039478

Biological Activity

[Description]:

Crenigacestat (LY3039478) is a novel and potent Notch inhibitor.

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> Notch

Research Areas >> Cancer

[In Vivo]

In a xenograft tumor model, Crenigacestat (LY3039478) inhibit N1ICD cleavage and expression of Notch-regulated genes in the tumor microenvironment. Crenigacestat (LY3039478) is being investigated in Phase I.

[Related Small Molecules]

RO4929097 | YO-01027 | LY-411575 | Tangeretin | FLI-06 | Avagacestat | IMR-1 | BMS-983970 | Semagacestat(LY450139) | Z-Ile-Leu-aldehyde | Psoralidin | tCFA15

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
818.7±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₂H₂₃F₃N₄O₄

[ Molecular Weight ]:
464.438

[ Flash Point ]:
448.9±34.3 °C

[ Exact Mass ]:
464.167145

[ PSA ]:
111.63000

[ LogP ]:
1.83

[ Vapour Pressure ]:
0.0±3.1 mmHg at 25°C

[ Index of Refraction ]:
1.594

[ Storage condition ]:
-20℃

Related Compounds

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