FLT3-IN-5e
Names
[ CAS No. ]:
2093038-25-4
[ Name ]:
FLT3-IN-5e
Biological Activity
[Description]:
FLT3-IN-5e is a nove potent, selective FLT3 inhibitor with Kd of 3.6 nM, IC50 of <6 nM; has high potentcy against mutant FLT3 D835H, D835V, D835Y, ITD-D835V, ITD-F691L, K663Q, N841I, and R834Q (Kd=0.36-82 nM); shows weak (8-fold selectivity) activity for PDGFRB (28 nM) and the JAK1 JH2 domain (28 nM); possesses growth inhibitory potencies against MOLM13 FLT3-ITD and MOLM13 FLT3-ITD/D835Y cells.
[References]
References 1. Jarusiewicz JA, et al. ACS Omega. 2017 May 31;2(5):1985-2009. View Related Products by Target FLT3
Chemical & Physical Properties
[ Molecular Formula ]:
C18H19N5
[ Molecular Weight ]:
305.385
Related Compounds
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