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FLT3-IN-4

Names

[ CAS No. ]:
2304799-09-3

[ Name ]:
FLT3-IN-4

Biological Activity

[Description]:

FLT3-IN-4 is a potent and orally effective Fms-like tyrosine receptor kinase 3 (FLT3; IC50=7 nM) inhibitor for treating acute myelogenous leukemia[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FLT3

[In Vitro]

FLT3-IN-4 (Compound 9u) shows potent inhibitory activities against MV4-11 and Molm-13 cells with IC50 values are 0.089±0.001 nM and 0.022±0.003 nM, respectively[1].

[References]

[1]. Yuan X, et al. Identification of Pyrrolo[2,3- d]pyrimidine-Based Derivatives as Potent and Orally Effective Fms-like Tyrosine Receptor Kinase 3 (FLT3) Inhibitors for Treating Acute Myelogenous Leukemia. J Med Chem. 2019 Apr 25;62(8):4158-4173.

Chemical & Physical Properties

[ Molecular Formula ]:
C23H25N7O2

[ Molecular Weight ]:
431.49

[ Storage condition ]:
-20°C

Safety Information

[ Hazard Codes ]:
Xn

Related Compounds