PG-S3-001

Names

[ CAS No. ]:
2047372-50-7

[ Name ]:
PG-S3-001

Biological Activity

[Description]:

PG-S3-001 is a small molecule STAT3 inhibitor that binds to STAT3 protein potently with Kd of 324 nM by surface plasmon resonance; shows no effect in a kinome screen (>100 cancer-relevant kinases); inhibits phosphorylation of STAT3 at Y705, inhibits patient-derived pancreatic cancer cell proliferation in vitro and in vivo in the low micromolar range; exhibits in vivo efficacy on pancreatic cancer xenografts.

[References]

References 1. Arpin CC, et al. Mol Cancer Ther. 2016 May;15(5):794-805. View Related Products by Target STAT

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₂H₃₃F₅N₂O₅S

[ Molecular Weight ]:
652.677

Related Compounds

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