PG-S3-001
Names
[ CAS No. ]:
2047372-50-7
[ Name ]:
PG-S3-001
Biological Activity
[Description]:
PG-S3-001 is a small molecule STAT3 inhibitor that binds to STAT3 protein potently with Kd of 324 nM by surface plasmon resonance; shows no effect in a kinome screen (>100 cancer-relevant kinases); inhibits phosphorylation of STAT3 at Y705, inhibits patient-derived pancreatic cancer cell proliferation in vitro and in vivo in the low micromolar range; exhibits in vivo efficacy on pancreatic cancer xenografts.
[References]
References 1. Arpin CC, et al. Mol Cancer Ther. 2016 May;15(5):794-805. View Related Products by Target STAT
Chemical & Physical Properties
[ Molecular Formula ]:
C32H33F5N2O5S
[ Molecular Weight ]:
652.677