PG-11047

PG-11047 (CGC-11047) is a polyamine analogue. PG-11047 can be used for the research of breast cancer[1].

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

PG-11047 (13 nM-5 mM; 72 h) 抑制乳腺细胞系成员的生长，范围很广，基底样细胞系在低于管腔细胞系的浓度下受到抑制[ 1]. PG-11047 (0.3, 10, 300 μM; 48 h, 72 h) 在几乎不产生细胞凋亡的剂量下显示 S 期分数显着降低[1]。 Cell Cycle Analysis[1] Cell Line: Breast cancer cell lines Concentration: 0.3, 10, 300 μM Incubation Time: 48 h, 72 h Result: Significant decreased the fraction of cells in S-phase with increasing doses. Apoptosis Analysis[1] Cell Line: Breast cancer cell lines Concentration: 0.3, 10, 300 μM Incubation Time: 48 h, 72 h Result: Induced apoptosis at high concentrations.

[1]. Wen-Lin Kuo, et al. A systems analysis of the chemosensitivity of breast cancer cells to the polyamine analogue PG-11047. BMC Med. 2009 Dec 14;7:77.