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SAR405 R enantiomer

Names

[ CAS No. ]:
1946010-79-2

[ Name ]:
SAR405 R enantiomer

[Synonym ]:
4H-Pyrimido[1,2-a]pyrimidin-4-one, 9-[(5-chloro-3-pyridinyl)methyl]-6,7,8,9-tetrahydro-2-[(3R)-3-methyl-4-morpholinyl]-8-(trifluoromethyl)-, (8R)-
(8R)-9-[(5-Chloro-3-pyridinyl)methyl]-2-[(3R)-3-methyl-4-morpholinyl]-8-(trifluoromethyl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one

Biological Activity

[Description]:

SAR405 R enantiomer is the less active enantiomer of SAR405. SAR405 is a PIK3C3/Vps34 inhibitor.

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Cancer

[References]

[1]. Pasquier B. SAR405, a PIK3C3/Vps34 inhibitor that prevents autophagy and synergizes with MTOR inhibition in tumor cells. Autophagy. 2015 Apr 3;11(4):725-6.


[Related Small Molecules]

Captisol | Cyclosporin A | H2DCFDA | 0MPTP hydrochloride | GW4869 | Etomoxir | TD139 | Mitoquinone mesylate | GSK2795039 | JC-1 | BAPTA-AM | AP 20187 | Setanaxib (GKT137831) | D-Luciferin | Crotaline

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
526.5±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C19H21ClF3N5O2

[ Molecular Weight ]:
443.850

[ Flash Point ]:
272.2±32.9 °C

[ Exact Mass ]:
443.133575

[ LogP ]:
1.97

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.635

[ Storage condition ]:
2-8℃

Related Compounds