GLPG0492 (R enantiomer)

Names

[ Name ]:
GLPG0492 (R enantiomer)

[Synonym ]:
(R)-4-[2,5-dioxo-4-hydroxymethyl-3-methyl-4-phenylimidazolidin-1-yl]-2-trifluoromethylbenzonitrile
GLPG0492 (R enantiomer)

Biological Activity

[Description]:

GLPG0492 R enantiomer is the R enantiomer of GLPG-0492, which is a novel selective androgen receptor modulator.

[Related Catalog]:

Signaling Pathways >> Others >> Androgen Receptor

Research Areas >> Others

[References]

[1]. Nique F, et al. Identification of a 4-(hydroxymethyl)diarylhydantoin as a selective androgen receptor modulator. J Med Chem. 2012 Oct 11;55(19):8236-47.

[2]. Cozzoli A, et al. GLPG0492, a novel selective androgen receptor modulator, improves muscle performance in the exercised-mdx mouse model of muscular dystrophy. Pharmacol Res. 2013 Jun;72:9-24.

[3]. Blanqué R, et al. Characterization of GLPG0492, a selective androgen receptor modulator, in a mouse model of hindlimb immobilization. BMC Musculoskelet Disord. 2014 Sep 3;15:291.

[Related Small Molecules]

ARN-509 | Dehydroepiandrosterone | Flutamide | ODM-201 | Danazol | 3,3'-Diindolylmethane | AZD3514 | RAD140 | BMS-564929 | GLPG0492 | Cyproterone acetate | LGD-4033 | Lupeol | Andarine | MK-0773

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₁₄F₃N₃O₃

[ Molecular Weight ]:
389.32800

[ Exact Mass ]:
389.09900

[ PSA ]:
84.64000

[ LogP ]:
2.86618

[ Storage condition ]:
2-8℃

GLPG0492 (R enantiomer)

Names

Biological Activity

Chemical & Physical Properties

Related Compounds