Azido-PEG6-PFP ester

Names

[ Name ]:
Azido-PEG6-PFP ester

[Synonym ]:
3,6,9,12,15,18-Hexaoxaheneicosan-21-oic acid, 1-azido-, 2,3,4,5,6-pentafluorophenyl ester
Pentafluorophenyl 1-azido-3,6,9,12,15,18-hexaoxahenicosan-21-oate
MFCD26793784

Biological Activity

[Description]:

Azido-PEG6-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₂₈F₅N₃O₈

[ Molecular Weight ]:
545.454

[ Exact Mass ]:
545.179626

[ LogP ]:
0.95

Azido-PEG6-PFP ester

Names

Biological Activity

Chemical & Physical Properties

Related Compounds