RORγt Inverse agonist 2

Names

[ CAS No. ]:
1801197-92-1

[ Name ]:
RORγt Inverse agonist 2

Biological Activity

[Description]:

RORγt Inverse agonist 2 is a selective, orally active RORγt inverse agonist with an EC50 of 119 nM[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> ROR
Research Areas >> Inflammation/Immunology

[Target]

EC50: 119 nM (RORγt)[1]


[In Vitro]

RORγt Inverse agonist 2 (Compound 26) is inactive against RORα and RORβ in either inverse agonist or agonist mode (>40 μM)[1].

[References]

[1]. Duan JJ, et al. Structure-based Discovery of Phenyl (3-Phenylpyrrolidin-3-yl)sulfones as Selective, Orally Active RORγt Inverse Agonists. ACS Med Chem Lett. 2019 Feb 26;10(3):367-373.

Chemical & Physical Properties

[ Molecular Formula ]:
C27H25F8NO5S

[ Molecular Weight ]:
627.54

Related Compounds