Sigma-1 receptor antagonist 2

Names

[ Name ]:
Sigma-1 receptor antagonist 2

Biological Activity

[Description]:

Sigma-1 receptor antagonist 2 is a potent and selective sigma 1 receptor (σ1 R) antagonist with Kis of 3.88 and 1288 nM for σ1 and σ2 receptor, respectively[1].

[Target]

Ki: 3.88 nM (σ1 receptor), 1288 nM (σ2 receptor)[1]

[References]

[1]. Lan Y, et al. Synthesis and biological evaluation of novel sigma-1 receptor antagonists based on pyrimidine scaffold as agents for treating neuropathic pain. J Med Chem. 2014 Dec 26;57(24):10404-23.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₂₆ClN₃O₂

[ Molecular Weight ]:
375.89

Sigma-1 receptor antagonist 2

Names

Biological Activity

Chemical & Physical Properties

Related Compounds