Sigma-1 receptor antagonist 3
Names
[ CAS No. ]:
1639220-17-9
[ Name ]:
Sigma-1 receptor antagonist 3
Biological Activity
[Description]:
Sigma-1 receptor antagonist 3 (compound135) is a potent and selective Sigma-1 (σ1) receptor antagonist with a Ki of 1.14 nM. Sigma-1 receptor antagonist 3 inhibits Human Ether-a-go-go-Related Gene (hERG) with an IC50 of 1.54 μM. Sigma-1 receptor antagonist 3 is for treating neuropathic pain[1].
[Target]
IC50: 1.54μM (hERG)[1]. Ki : 1.14 nM (Sigma-1 receptor); 1239 nM (Sigma-2 receptor) [1]
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C19H23ClFN3O
[ Molecular Weight ]:
363.86