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EMT inhibitor-1

Names

[ CAS No. ]:
1638526-21-2

[ Name ]:
EMT inhibitor-1

Biological Activity

[Description]:

EMT inhibitor-1 is an inhibitor of of Hippo, TGF-β, and Wnt signaling pathways with antitumor activities.

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> Hippo (MST)
Signaling Pathways >> Stem Cell/Wnt >> TGF-beta/Smad
Signaling Pathways >> TGF-beta/Smad >> TGF-beta/Smad
Signaling Pathways >> Stem Cell/Wnt >> Wnt
Research Areas >> Cancer

[Target]

Hippo, TGF-β, Wnt[1].


[In Vitro]

EMT inhibitor-1 (C19) is an inhibitor of of Hippo, TGF-β, and Wnt signaling pathways with antitumor activities, inhibiting cancer cell migration, proliferation, and resistance to doxorubicin in vitro[1].

[In Vivo]

EMT inhibitor-1 (C19) exerts strong antitumor activity in a mouse tumor model. Mechanistically, EMT inhibitor-1 induces GSK3-β–mediated degradation of the Hippo transducer TAZ, through activation of the Hippo kinases Mst/Lats and the tumor suppressor kinase AMPK upstream of the degradation complex[1].

[References]

[1]. Basu D, et al. Identification, mechanism of action, and antitumor activity of a small molecule inhibitor of hippo, TGF-β, and Wnt signaling pathways. Mol Cancer Ther. 2014 Jun;13(6):1457-67.


[Related Small Molecules]

XMU MP 1 | ICG-001 | SIS3 | Salinomycin | Pirfenidone | IWR-1 | Kartogenin | Wnt-C59 | Berberine chloride hydrate | Pyrvinium pamoate | Disitertide | ETC-159 | BML 284 | IWP-2

Chemical & Physical Properties

[ Molecular Formula ]:
C12H12Cl2N2O2S

[ Molecular Weight ]:
319.21

[ Storage condition ]:
2-8℃

Related Compounds