Disitertide

Names

[ CAS No. ]:
272105-42-7

[ Name ]:
Disitertide

[Synonym ]:
tsldasiiwammqn

Biological Activity

[Description]:

Disitertide is an inhibitor of TGF-β1. Sequence: Thr-Ser-Leu-Asp-Ala-Ser-Ile-Ile-Trp-Ala-Met-Met-Gln-Asn.

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> TGF-beta/Smad

Signaling Pathways >> TGF-beta/Smad >> TGF-beta/Smad

Research Areas >> Cancer

Peptides

[In Vitro]

Disitertide (P144) prevents TGF-β1-dependent inhibition of MV1Lu proliferation in vitro and markedly reduces binding of TGF-β1 to its receptors. Disitertide blocks TGF-β1-dependent stimulation of a reporter gene under the control of human α2(I) collagen promoter[1].

[In Vivo]

Treatment with Disitertide at low doses causes a significant inhibition of HSC activation and a marked reduction in liver fibrosis in a rat model of chronic exposure to CCl4. A dose as low as 70 μg of the 15-mer peptide Disitertide, given to rats (300 g body weight) on alternate days, decreases fibrogenesis significantly during chronic exposure to CCl4[1].

[References]

[1]. Ezquerro IJ et al. A synthetic peptide from transforming growth factor beta type III receptor inhibits liver fibrogenesis in rats with carbon tetrachloride liver injury. Cytokine. 2003 Apr;22(1-2):12-20.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.327g/cm3

[ Boiling Point ]:
1968.718ºC at 760 mmHg

[ Molecular Formula ]:
C₆₈H₁₀₉N₁₇O₂₂S₂

[ Molecular Weight ]:
1580.82000

[ Exact Mass ]:
1579.74000

[ PSA ]:
692.18000

[ LogP ]:
1.27260

[ Storage condition ]:
-20°C