S-sulfo-L-cysteine

Names

[ Name ]:
S-sulfo-L-cysteine

[Synonym ]:
S-Sulfocysteine
S-sulpho-L-cysteine
Cysteinyl-S-sulfonate
S-Sulfo-L-cystein
S-Sulphocysteine
L-Cysteine S-sulfate
(2R)-2-amino-3-sulfosulfanylpropanoic acid
Cysteine-S-sulfonate
S-Sulfo-L-cysteine
Cysteine-S-sulfate
Cysteinyl-S-sulfonic acid
MFCD00133440

Biological Activity

[Description]:

L-Cysteine S-sulfate is a potent N-methyl-d-aspartate (NMDA) glutamatergic receptors agonist. L-Cysteine S-sulfate is the substrate for cystine lyase[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> iGluR

Research Areas >> Neurological Disease

Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR

[Target]

Human Endogenous Metabolite

[References]

[1]. Steventon GB, et, al. Comparison of the sulfur-oxygenation of cysteine and S-carboxymethyl-l-cysteine in human hepatic cytosol and the rôle of cysteine dioxygenase. J Pharm Pharmacol. 2018 Aug;70(8):1069-1077.

Chemical & Physical Properties

[ Melting Point ]:
184-185ºC

[ Molecular Formula ]:
C₃H₇NO₅S₂

[ Molecular Weight ]:
201.22100

[ Exact Mass ]:
200.97700

[ PSA ]:
151.37000

[ LogP ]:
0.71540

[ Index of Refraction ]:
1.604

[ Storage condition ]:
−20°C

[ Stability ]:
Store in Freezer at -20°C

[ Water Solubility ]:
H2O: 20 mg/mL, clear, colorless

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2930909090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2930909090

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Dietary therapy in two patients with a mild form of sulphite oxidase deficiency. Evidence for clinical and biological improvement.

J. Inherit. Metab. Dis. 23(1) , 45-53, (2000)

We report an attempt at dietetic therapy in two unrelated patients with isolated sulphite oxidase deficiency, with a mild clinical course and late onset of symptoms. In case 1, disease started at 15 m...

Urinary AASA excretion is elevated in patients with molybdenum cofactor deficiency and isolated sulphite oxidase deficiency.

J. Inherit. Metab. Dis. 35(6) , 1031-6, (2012)

Analysis of α-aminoadipic semialdehyde is an important tool in the diagnosis of antiquitin deficiency (pyridoxine-dependent epilepsy). However continuing use of this test has revealed that elevated ur...

Molybdenum cofactor deficiency: metabolic link between taurine and S-sulfocysteine.

Adv. Exp. Med. Biol. 776 , 13-9, (2013)

Molybdenum cofactor deficiency (MoCD) is a rare inherited metabolic disorder characterized by severe and progressive neurologic damage mainly caused by the loss of sulfite oxidase activity. Elevated u...

Related Compounds

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