Neamine tetrahydrochloride

Names

[ Name ]:
Neamine tetrahydrochloride

[Synonym ]:
neamine hydrochloride

Biological Activity

[Description]:

Neamine tetrahydrochloride, a degradation product of Neomycin, is a broad-spectrum aminoglycoside antibiotic. Neamine tetrahydrochloride is an anti-angiogenesis agent targeting angiogenin. Neamine tetrahydrochloride has potent antibacterial, antitumor and neuroprotective activities[1][2].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Infection

Research Areas >> Neurological Disease

Signaling Pathways >> Anti-infection >> Bacterial

[In Vitro]

Neamine (0.625-25 μM; 48 hours; AsPC-1 cells) treatment inhibits ANG-mediated AsPC-1 cell proliferation in a dose-dependent manner in the range of 0.625-25 μM[1]. Neamine (100 μM) also blocks the nuclear translocation of ANG effectively[1]. Cell Proliferation Assay[1] Cell Line: AsPC-1 cells Concentration: 0.625 µM, 1.25 µM, 2.5 µM, 5 µM, 10 µM, 25 µM Incubation Time: 48 hours Result: Inhibited angiogenin (ANG)-induced AsPC-1 cells proliferation.

[In Vivo]

Neamine (30-60 mg/kg; subcutaneous injection; daily; for 14 days; male Balb/c nude mice) has anti-tumor effects on AsPC-1 xenograft models. Neamine reduces the expression levels of ANG, Ki-67 and CD31 in tumor xenografts[1]. Animal Model: Male Balb/c nude mice (4 weeks old) injected with AsPC-1 cells[1] Dosage: 30 mg/kg, 60 mg/kg Administration: Subcutaneous injection; daily; for 14 days Result: Had anti-tumor effects on AsPC-1 xenograft models.

[References]

[1]. Ya-Ping Liu, et al. Neamine Inhibits Growth of Pancreatic Cancer Cells in Vitro and in Vivo. J Huazhong Univ Sci Technolog Med Sci. 2016 Feb;36(1):82-87.

[2]. R Ning, et al. Neamine Induces Neuroprotection After Acute Ischemic Stroke in Type One Diabetic Rats. Neuroscience. 2014 Jan 17;257:76-85.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₂H₃₀Cl₄N₄O₆

[ Molecular Weight ]:
468.20200

[ Exact Mass ]:
466.09200

[ PSA ]:
203.46000

[ LogP ]:
0.89360

Synthetic Route

Click to get detail synthetic route

Related Compounds

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