α-Synuclein (61-95) (human) trifluoroacetate salt

Names

[ Name ]:
α-Synuclein (61-95) (human) trifluoroacetate salt

[Synonym ]:
GLU-GLN-VAL-THR-ASN-VAL-GLY-GLY-ALA-VAL-VAL-THR-GLY-VAL-THR-ALA-VAL-ALA-GLN-LYS-THR-VAL-GLU-GLY-ALA-GLY-SER-ILE-ALA-ALA-ALA-THR-GLY-PHE-VAL

Biological Activity

[Description]:

α-Synuclein (61-95) (human) is the hydrophobic core region of α-synuclein, and induces neuronal cell death. α-Synuclein (61-95) (human) can be used for research of neurodegenerative diseases, including Alzheimer’s disease (AD) and Parkinson’s disease (PD)[1][2].

[Related Catalog]:

Research Areas >> Neurological Disease

[References]

[1]. Tabner BJ, et al. Formation of hydrogen peroxide and hydroxyl radicals from A(beta) and alpha-synuclein as a possible mechanism of cell death in Alzheimer's disease and Parkinson's disease. Free Radic Biol Med. 2002 Jun 1;32(11):1076-83.

[2]. Emadi S, et al. Inhibiting aggregation of alpha-synuclein with human single chain antibody fragments. Biochemistry. 2004 Mar 16;43(10):2871-8.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
2937.7±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₄₁H₂₃₅N₃₉O₄₉

[ Molecular Weight ]:
3260.61

[ Flash Point ]:
1730.4±34.3 °C

[ Exact Mass ]:
3258.709473

[ LogP ]:
-6.81

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.553

[ Storage condition ]:
−20°C

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Suppression of Cpn10 increases mitochondrial fission and dysfunction in neuroblastoma cells.

PLoS ONE 9(11) , e112130, (2014)

To date, several regulatory proteins involved in mitochondrial dynamics have been identified. However, the precise mechanism coordinating these complex processes remains unclear. Mitochondrial chapero...

Ellipticine induces apoptosis in T-cell lymphoma via oxidative DNA damage.

Leuk. Lymphoma 56(3) , 739-47, (2015)

The tumor suppressor p53 is often mutated in human cancers. Restoring its antitumor activity has been shown to be a promising therapeutic approach for cancer treatment. Here we analyzed the activity a...

Antiviral effect of methylated flavonol isorhamnetin against influenza.

PLoS ONE 10(3) , e0121610, (2015)

Influenza is an infectious respiratory disease with frequent seasonal epidemics that causes a high rate of mortality and morbidity in humans, poultry, and animals. Influenza is a serious economic conc...