AB-MECA

Names

[ CAS No. ]:
152918-26-8

[ Name ]:
AB-MECA

[Synonym ]:
N6-(4-Aminobenzyl)-N-methylcarboxamidoadenosine
[3H]AB-MECA
AB-MECA

Biological Activity

[Description]:

AB-MECA is a high affinity A3 adenosine receptor agonist, has high affinity for recombinant A1 and A3 receptors.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor

Research Areas >> Neurological Disease

[References]

[1]. Shearman LP, et al. [125I]4-aminobenzyl-5'-N-methylcarboxamidoadenosine (125I)AB-MECA) labels multiple adenosine receptorsubtypes in rat brain. Brain Res. 1997 Jan 16;745(1-2):10-20.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.68g/cm3

[ Molecular Formula ]:
C₁₈H₂₁N₇O₄

[ Molecular Weight ]:
399.40400

[ Exact Mass ]:
399.16600

[ PSA ]:
163.93000

[ LogP ]:
0.88030

[ Index of Refraction ]:
1.789

[ Storage condition ]:
2-8℃

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

125I-4-aminobenzyl-5'-N-methylcarboxamidoadenosine, a high affinity radioligand for the rat A3 adenosine receptor.

Mol. Pharmacol. 45 , 978-982, (1994)

The rat A3 adenosine receptor (AR) is a recently characterized AR subtype cloned from testis and brain cDNA libraries. N6-2-(4-Amino-3-[125I]iodophenyl)ethyladenosine, a high affinity A1AR agonist, ha...

A role for central A3-adenosine receptors. Mediation of behavioral depressant effects.

FEBS Lett. 336 , 57-60, (1993)

The behavioral effects of a selective A3 adenosine receptor agonist 3-IB-MECA (N6-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine) in mice and the localization of radioligand binding sites in mouse bra...

Structure-activity relationships of N6-benzyladenosine-5'-uronamides as A3-selective adenosine agonists.

J. Med. Chem. 37 , 636-646, (1994)

Adenosine analogues modified at the 5'-position as uronamides and/or as N6-benzyl derivatives were synthesized. These derivatives were examined for affinity in radioligand binding assays at the newly ...