Sucralose-d6

Names

[ Name ]:
Sucralose-d6

[Synonym ]:
α-D-Galactopyranoside-C6,C6-d2, 1,6-dichloro-1,6-dideoxy-β-D-fructofuranosyl-1,1,6,6-d4 4-chloro-4-deoxy-
SUCRALOSE-D6
1,6-Dichloro-1,6-dideoxy-β-D-(1,1,6,6-2H4)fructofuranosyl 4-chloro-4-deoxy-α-D-(C6,C6-2H2)galactopyranoside

Biological Activity

[Description]:

Sucralose-d6 is deuterium labeled Sucralose. Sucralose (E955; Trichlorosucrose) is a non-nutritive artificial sweetener and sugar substitute. Sucralose can activate a conserved neural fasting response and thereby exerts an appetite-stimulating effect in rodents[1][2].

[Related Catalog]:

Research Areas >> Cancer

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. M S, et al. Sucralose administered in feed, beginning prenatally through lifespan, induces hematopoietic neoplasias in male swiss mice. Int J Occup Environ Health. 2016 Jan;22(1):7-17.

[3]. Nabanita Kundu, et al. Sucralose promotes accumulation of reactive oxygen species (ROS) and adipogenesis in mesenchymal stromal cells. Stem Cell Res Ther. 2020 Jun 26;11(1):250.

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
669.4±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₂H₁₃D₆Cl₃O₈

[ Molecular Weight ]:
403.67

[ Flash Point ]:
358.7±31.5 °C

[ Exact Mass ]:
402.052216

[ LogP ]:
0.68

[ Vapour Pressure ]:
0.0±4.6 mmHg at 25°C

[ Index of Refraction ]:
1.604

Related Compounds

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