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LEE011-D6

Names

[ CAS No. ]:
1328934-40-2

[ Name ]:
LEE011-D6

Biological Activity

[Description]:

Ribociclib D6 (LEE011 D6) is a deuterium labeled Ribociclib. Ribociclib is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> CDK

[References]

[1]. VanArsdale T, et al. Molecular Pathways: Targeting the Cyclin D-CDK4/6 Axis for Cancer Treatment. Clin Cancer Res. 2015 Jul 1;21(13):2905-10.

Chemical & Physical Properties

[ Molecular Formula ]:
C23H24D6N8O

[ Molecular Weight ]:
440.57

Related Compounds