ENMD-2076 tartrate

Names

[ Name ]:
ENMD-2076 tartrate

[Synonym ]:
ENMD-2076
MFCD18074523
KXQ762CQTH
(2R,3R)-2,3-Dihydroxysuccinic acid - 6-(4-methyl-1-piperazinyl)-N-(5-methyl-1H-pyrazol-3-yl)-2-[(E)-2-phenylvinyl]-4-pyrimidinamine (1:1)
Butanedioic acid, 2,3-dihydroxy-, (2R,3R)-, compd. with 6-(4-methyl-1-piperazinyl)-N-(5-methyl-1H-pyrazol-3-yl)-2-[(E)-2-phenylethenyl]-4-pyrimidinamine (1:1)
MFCD18633211

Biological Activity

[Description]:

A multitargeted kinase inhibitor with IC50s of 3/14/23/40 nM for Flt3/Aurora A/Src/VEGFR2.

[In Vitro]

A multitargeted kinase inhibitor with IC50s of 3/14/23/40 nM for Flt3/Aurora A/Src/VEGFR2; also inhibits Aurora B, c-Kit, FGFR1 (IC50=100-350 nM); orally bioactive.Liver CancerPhase 2 Clinical

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₅H₃₁N₇O₆

[ Molecular Weight ]:
525.557

[ Exact Mass ]:
525.233582

Related Compounds

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