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Ledipasvir (acetone)

Names

[ CAS No. ]:
1441674-54-9

[ Name ]:
Ledipasvir (acetone)

[Synonym ]:
Ledipasvir (acetone)
Carbamic acid, N-[(1S)-1-[[(6S)-6-[5-[9,9-difluoro-7-[2-[(1R,3S,4S)-2-[(2S)-2-[(methoxycarbonyl)amino]-3-methyl-1-oxobutyl]-2-azabicyclo[2.2.1]hept-3-yl]-1H-benzimidazol-6-yl]-9H-fluoren-2-yl]-1H-imidazol-2-yl]-5-azaspiro[2.4]hept-5-yl]carbonyl]-2-methylpropyl]-, methyl ester, compd. with 2-propanone (1:1)
Ledipasvir compd. with acetone
Methyl [(2S)-1-{(1R,3S,4S)-3-[6-(9,9-difluoro-7-{2-[(6S)-5-{(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl}-5-azaspiro[2.4]hept-6-yl]-1H-imidazol-5-yl}-9H-fluoren-2-yl)-1H-benzimidazol-2-yl]-2-azabicyclo[2.2.1]hept-2-yl}-3-methyl-1-oxo-2-butanyl]carbamate - acetone (1:1)
Ledipasvir (GS5885) acetone

Biological Activity

[Description]:

Ledipasvir acetone is the active pharmaceutical ingredient of Ledipasvir. Ledipasvir is an inhibitor of the hepatitis C virus NS5A, with EC50 values of 34 pM against GT1a and 4 pM against GT1b replicon.

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> HCV Protease
Signaling Pathways >> Anti-infection >> HCV
Research Areas >> Infection

[In Vitro]

Ledipasvir acetone is considered the active pharmaceutical ingredient, which is converted to Ledipasvir spray-dried dispersion, an amorphous free base.

[Related Small Molecules]

Asunaprevir | Sofosbuvir | Simeprevir | Ledipasvir | paritaprevir | Artemisinin | Elbasvir | NIM811 | MK-5172 | velpatasvir | Ombitasvir | Danoprevir (ITMN-191) | Glecaprevir | Celgosivir (hydrochloride) | Alisporivir

Chemical & Physical Properties

[ Molecular Formula ]:
C52H60F2N8O7

[ Molecular Weight ]:
947.079

[ Exact Mass ]:
946.455322

[ PSA ]:
191.71000

[ LogP ]:
9.86020

[ Storage condition ]:
2-8℃

Related Compounds