Seclidemstat

Names

[ Name ]:
Seclidemstat

[Synonym ]:
N'-[(1E)-1-(5-Chloro-2-hydroxyphenyl)ethylidene]-3-[(4-methyl-1-piperazinyl)sulfonyl]benzohydrazide
TYH386V3WJ
Benzoic acid, 3-[(4-methyl-1-piperazinyl)sulfonyl]-, 2-[(1E)-1-(5-chloro-2-hydroxyphenyl)ethylidene]hydrazide

Biological Activity

[Description]:

Seclidemstat (SP-2577) is a potent LSD1 inhibitor, with a mean IC50 of 127 nM.

[Related Catalog]:

Signaling Pathways >> Epigenetics >> Histone Demethylase

Research Areas >> Cancer

[Target]

IC50: 127 nM (LSD1)[1]

[In Vivo]

Seclidemstat (Compound 2577) reduces tumor volume at 40, 80 mg/kg by i.p. and also shows such effect at 80 mg/kg via p.o. dosing.

[References]

[1]. SUBSTITUTED BENZOHYDRAZIDE ANALOGS AS HISTONE DEMETHYLASE INHIBITORS. WO/2017/004519 A1

[Related Small Molecules]

GSK-J4 | QC6352 | GSK2879552 | SP-2509 | CPI-455 | trans-2-Phenylcyclopropylamine hemisulfate salt | 5-Carboxy-8-hydroxyquinoline | ML324 | GSK-LSD1 Dihydrochloride | NCGC00244536 | Daminozide | ORY-1001(trans) | JIB-04 | AS 8351 | KDM5-IN-1

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Molecular Formula ]:
C₂₀H₂₃ClN₄O₄S

[ Molecular Weight ]:
450.939

[ Exact Mass ]:
450.112854

[ LogP ]:
4.07

[ Index of Refraction ]:
1.645

[ Storage condition ]:
2-8℃

Related Compounds

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