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Bromoacetamido-PEG2-C2-acid

Names

[ CAS No. ]:
1415800-44-0

[ Name ]:
Bromoacetamido-PEG2-C2-acid

[Synonym ]:
MFCD22683317
Propanoic acid, 3-[2-[2-[(2-bromoacetyl)amino]ethoxy]ethoxy]-
3-(2-{2-[(Bromoacetyl)amino]ethoxy}ethoxy)propanoic acid

Biological Activity

[Description]:

Bromoacetamido-PEG2-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
491.4±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C9H16BrNO5

[ Molecular Weight ]:
298.131

[ Flash Point ]:
251.0±28.7 °C

[ Exact Mass ]:
297.021179

[ LogP ]:
-0.59

[ Vapour Pressure ]:
0.0±2.7 mmHg at 25°C

[ Index of Refraction ]:
1.503

Related Compounds