Tylosin phosphate

Names

[ Name ]:
Tylosin phosphate

[Synonym ]:
Pharmasine TB
MFCD06795692
Einecs 215-779-4
Tylan 10 premix
UNII:NR75X12AFF
TYLOSIN PHOSPHATE PREMIX
Farmazin TB
Tylan 40 premix
[(2R,3R,4E,6E,9R,11R,12S,13S,14R)-12-{[3,6-Dideoxy-4-O-(2,6-dideoxy-3-C-methyl-α-L-ribo-hexopyranosyl)-3-(dimethylamino)-β-D-glucopyranosyl]oxy}-2-ethyl-14-hydroxy-5,9,13-trimethyl-8,16-dioxo-1 1-(2-oxoethyl)oxacyclohexadeca-4,6-dien-3-yl]methyl 6-deoxy-2,3-di-O-methyl-β-D-allopyranoside phosphate (1:1)
TylosinPhosphate
TYLAN
Oxacyclohexadeca-11,13-diene-7-acetaldehyde, 15-[[(6-deoxy-2,3-di-O-methyl-β-D-allopyranosyl)oxy]methyl]-6-[[3,6-dideoxy-4-O-(2,6-dideoxy-3-C-methyl-α-L-ribo-hexopyranosyl)-3-(dimethylamino)-be ta-D-glucopyranosyl]oxy]-16-ethyl-4-hydroxy-5,9,13-trimethyl-2,10-dioxo-, (4R,5S,6S,7R,9R,11E,13E,15R,16R)-, phosphate (1:1) (salt)
Tylosin (phosphate)

Biological Activity

[Description]:

Tylosin phosphate(Fradizine; Tylocine; Tylosin A) is a broad spectrum antibiotic against Gram-positive organisms and a limited range of Gram-negative organisms.

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Bacterial

Research Areas >> Infection

[References]

[1]. Pilcher CM, et al. Impact of tylosin phosphate and distillers dried grains with solubles on energy and nutrient digestibility and flow through the gastrointestinal tract in growing pigs. J Anim Sci. 2013 Dec;91(12):5687-95.

[2]. Entorf M, et al. Tylosin susceptibility of staphylococci from bovine mastitis. Vet Microbiol. 2014 Jul 16;171(3-4):368-73.

[Related Small Molecules]

Chemical & Physical Properties

[ Boiling Point ]:
980.7ºC at 760 mmHg

[ Molecular Formula ]:
C₄₆H₈₀NO₂₁P

[ Molecular Weight ]:
1014.095

[ Flash Point ]:
546.9ºC

[ Exact Mass ]:
1013.496033

[ PSA ]:
326.24000

[ LogP ]:
0.90490

[ Vapour Pressure ]:
0mmHg at 25°C

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xn

[ Safety Phrases ]:
S22

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
YP0625000

[ HS Code ]:
2941909000

Customs

[ HS Code ]: 2941909000

Articles

Fungal recognition enhances mannose receptor shedding through dectin-1 engagement.

J. Biol. Chem. 286(10) , 7822-9, (2011)

The mannose receptor (MR) is an endocytic type I membrane molecule with a broad ligand specificity that is involved in both hemostasis and pathogen recognition. Membrane-anchored MR is cleaved by a me...

Effect of subtherapeutic vs. therapeutic administration of macrolides on antimicrobial resistance in Mannheimia haemolytica and enterococci isolated from beef cattle.

Front. Microbiol. 4 , 133, (2013)

Macrolides are the first-line treatment against bovine respiratory disease (BRD), and are also used to treat infections in humans. The macrolide, tylosin phosphate, is often included in the diet of ca...

[Toxicological studies of a combination of technical tylosin phosphate with bentonite (farmazin TB)].

Vet. Med. Nauki 20(5-6) , 80-6, (1983)

Studied were both the acute and subchronic toxicity of technical tylosine phosphate (TP), produced at the Research Chemical and Pharmaceutical Institute, Sofia, used in combination with bentonite, kno...

Related Compounds

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