A 1070722

Names

[ Name ]:
A 1070722

[Synonym ]:
1-(7-Methoxyquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea
Zatebradine hydrochloride
1-(7-Methoxy-4-quinolinyl)-3-[6-(trifluoromethyl)-2-pyridinyl]urea
A 1070722

Biological Activity

[Description]:

A 1070722 is a potent and selective glycogen synthase kinase 3 (GSK-3) inhibitor, with a Ki of 0.6 nM for both GSK-3α and GSK-3β. A 1070722 can penetrate the blood-brain barrier (BBB) and accumulates in brain regions, thus potential for PET radiotracer for the quantification of GSK-3 in brain[1].

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> GSK-3

Research Areas >> Cancer

Signaling Pathways >> PI3K/Akt/mTOR >> GSK-3

[Target]

GSK-3α:0.6 nM (Ki)

GSK-3β:0.6 nM (Ki)

[References]

[1]. Prabhakaran J, et al. Radiosynthesis and in Vivo Evaluation of [11C]A1070722, a High Affinity GSK-3 PET Tracer in Primate Brain. ACS Chem Neurosci. 2017 Aug 16;8(8):1697-1703.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
412.5±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₇H₁₃F₃N₄O₂

[ Molecular Weight ]:
362.306

[ Flash Point ]:
203.3±28.7 °C

[ Exact Mass ]:
362.099060

[ PSA ]:
79.63000

[ LogP ]:
4.36

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.653

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H315-H319-H335

[ Precautionary Statements ]:
P261-P301 + P310-P305 + P351 + P338

[ RIDADR ]:
UN 2811 6.1 / PGIII