LAS-31180

Names

[ CAS No. ]:
137338-43-3

[ Name ]:
LAS-31180

[Synonym ]:
1-methyl-3-methylsulfonylamino-4(1H) quinolone
N-(1-METHYL-4-OXO-QUINOLIN-3-YL)METHANESULFONAMIDE
n-(1-methyl-4-oxo-1,4-dihydroquinolin-3-yl)methanesulfonamide
LAS-31180

Biological Activity

[Description]:

LAS-31180 is an inhibitor of phosphodiesterase 3, with positive inotropic and vasodilator properties.

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)
Research Areas >> Cardiovascular Disease

[In Vitro]

LAS 31180 shows positive inotropic activities in isolated guinea-pig ventricular strips (EC50 of 1.2 mumol/L) and in isolated guinea-pig working hearts[1].

[In Vivo]

In conscious chronically instrumented beagle dogs, LAS 31180 administered either by intravenous or oral route, shows a dose-dependent, long-lasting positive inotropic effect with minimal effects on heart rate. In hypertensive beagle dogs LAS 31180 elicits a potent and long-lasting fall in blood pressure[1].

[References]

[1]. Gras J, et al. Pharmacological profile of LAS 31180, a new inotropic/vasodilator quinolone derivative. Arzneimittelforschung. 2000 Nov;50(11):980-6.


[Related Small Molecules]

3-Isobutyl-1-methylxanthine | rolipram | PF-04957325 | AN-2728 | GLPG1690 | BAY-60-7550 | Icariin | Ibudilast | PF-8380 | TAK-063 | Dipyridamole | Cilostazol | GSK256066 | Cialis | Pentoxifylline

Chemical & Physical Properties

[ Molecular Formula ]:
C11H12N2O3S

[ Molecular Weight ]:
252.29000

[ Exact Mass ]:
252.05700

[ PSA ]:
76.55000

[ LogP ]:
2.06380

[ Storage condition ]:
2-8℃

Related Compounds