137338-43-3

137338-43-3 structure

Name: LAS-31180
Chemical Name: N-(1-methyl-4-oxoquinolin-3-yl)methanesulfonamide
CAS Number: 137338-43-3
Molecular Formula: C₁₁H₁₂N₂O₃S
Molecular Weight: 252.29000
Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphodiesterase (PDE)
Create Date: 2017-07-03 10:28:37
Modify Date: 2024-01-23 15:16:46
LAS-31180 is an inhibitor of phosphodiesterase 3, with positive inotropic and vasodilator properties.

Name	N-(1-methyl-4-oxoquinolin-3-yl)methanesulfonamide
Synonyms	1-methyl-3-methylsulfonylamino-4(1H) quinolone N-(1-METHYL-4-OXO-QUINOLIN-3-YL)METHANESULFONAMIDE n-(1-methyl-4-oxo-1,4-dihydroquinolin-3-yl)methanesulfonamide LAS-31180

Description	LAS-31180 is an inhibitor of phosphodiesterase 3, with positive inotropic and vasodilator properties.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Research Areas >> Cardiovascular Disease
In Vitro	LAS 31180 shows positive inotropic activities in isolated guinea-pig ventricular strips (EC50 of 1.2 mumol/L) and in isolated guinea-pig working hearts[1].
In Vivo	In conscious chronically instrumented beagle dogs, LAS 31180 administered either by intravenous or oral route, shows a dose-dependent, long-lasting positive inotropic effect with minimal effects on heart rate. In hypertensive beagle dogs LAS 31180 elicits a potent and long-lasting fall in blood pressure[1].
References	[1]. Gras J, et al. Pharmacological profile of LAS 31180, a new inotropic/vasodilator quinolone derivative. Arzneimittelforschung. 2000 Nov;50(11):980-6.