ML 190

Names

[ CAS No. ]:
1355244-02-8

[ Name ]:
ML 190

[Synonym ]:
ML 190
GMQ hydrochloride

Biological Activity

[Description]:

ML 190 is a selective κ opioid receptor (KOR) antagonist with an IC50 of 120 nM and an EC50 of 129 nM, respectively[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Opioid Receptor

Signaling Pathways >> Neuronal Signaling >> Opioid Receptor

Research Areas >> Neurological Disease

[Target]

IC50: 120 nM (KOR)[1] EC50: 129 nM (KOR)[1]

[In Vitro]

ML 190 exhibits plasma protein binding of 93.96% (1 μM), 88.54% (10 μM) in human and 88.46% (1 μM), 80.07% (10 μM) in mouse, respectively; plasma remaining percents of 100% at 3 hours in both human and mouse; hepatic microsome remaining percents of 22.13% and 7.34% at 1 hour in human and mouse, respectively; and hepatic toxicity LC50 over 50 μM[1].

[References]

[1]. Frankowski KJ, et al. Discovery of Small Molecule Kappa Opioid Receptor Agonist and Antagonist Chemotypes through a HTS and Hit Refinement Strategy. ACS Chem Neurosci. 2012;3(3):221-236.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₇H₃₂N₆O₃

[ Molecular Weight ]:
488.58

[ Exact Mass ]:
488.25400

[ PSA ]:
84.11000

[ LogP ]:
2.68850

Related Compounds

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