ML 190
Names
Biological Activity
[Description]:
ML 190 is a selective κ opioid receptor (KOR) antagonist with an IC50 of 120 nM and an EC50 of 129 nM, respectively[1].
[Related Catalog]:
[Target]
IC50: 120 nM (KOR)[1] EC50: 129 nM (KOR)[1]
[In Vitro]
ML 190 exhibits plasma protein binding of 93.96% (1 μM), 88.54% (10 μM) in human and 88.46% (1 μM), 80.07% (10 μM) in mouse, respectively; plasma remaining percents of 100% at 3 hours in both human and mouse; hepatic microsome remaining percents of 22.13% and 7.34% at 1 hour in human and mouse, respectively; and hepatic toxicity LC50 over 50 μM[1].
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C27H32N6O3
[ Molecular Weight ]:
488.58
[ Exact Mass ]:
488.25400
[ PSA ]:
84.11000
[ LogP ]:
2.68850