HNMPA

Names

[ Name ]:
HNMPA

[Synonym ]:
2-naphthylhydroxymethylphosphonate

Biological Activity

[Description]:

HNMPA is a membrane impermeable insulin receptor tyrosine kinase inhibitor. HNMPA inhibits serine and tyrosine autophosphorylation by the human insulin receptor. HNMPA has no effect on protein kinase C or cyclic AMP-dependent protein kinase activities[1][2]

[Related Catalog]:

Research Areas >> Metabolic Disease

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Insulin Receptor

[In Vitro]

HNMPA inhibits the phosphorylation of a synthetic peptide substrate composed of insulin receptor residues 1290-1319 on serines-1305/1306 by partially purified insulin receptors[1]. HNMPA blocks GABA-dependent insulin inhibition, and reduces neuronal firing after GABA application[2].

[References]

[1]. K Baltensperger, et al. Catalysis of serine and tyrosine autophosphorylation by the human insulin receptor. Proc Natl Acad Sci U S A. 1992 Sep 1;89(17):7885-9.

[2]. Peter Kovacs, et al. In vivo electrophysiological effects of insulin in the rat brain. Neuropeptides. 2009 Aug;43(4):283-93.

Chemical & Physical Properties

[ Density]:
1.514g/cm3

[ Boiling Point ]:
527.2ºC at 760mmHg

[ Molecular Formula ]:
C₁₁H₁₁O₄P

[ Molecular Weight ]:
238.17600

[ Flash Point ]:
272.6ºC

[ Exact Mass ]:
238.03900

[ PSA ]:
87.57000

[ LogP ]:
2.00840

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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