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Suc-Ala-Glu-Pro-Phe-pNA

Names

[ CAS No. ]:
128802-76-6

[ Name ]:
Suc-Ala-Glu-Pro-Phe-pNA

[Synonym ]:
N-(3-Carboxypropanoyl)-L-alanyl-L-α-glutamyl-L-prolyl-N-(4-nitrophenyl)-L-phenylalaninamide
MFCD00238367
L-Phenylalaninamide, N-(3-carboxy-1-oxopropyl)-L-alanyl-L-α-glutamyl-L-prolyl-N-(4-nitrophenyl)-
Suc-Ala-Glu-Pro-Phe-pNA

Biological Activity

[Description]:

Suc-Ala-Glu-Pro-Phe-pNA (Suc-AEPF-pNA) is a chromogenic substrate for the peptidylprolyl isomerase Pin1. Suc-Ala-Glu-Pro-Phe-pNA can be used to evaluate the inhibitory effect of the target compound on Pin1, and catalytic activity of Pin1, etc[1][2].

[Related Catalog]:

Research Areas >> Others

[References]

[1]. Subedi A, et al. Discovery of novel selenium derivatives as Pin1 inhibitors by high-throughput screening. Biochem Biophys Res Commun. 2016 Jun 3;474(3):528-533.  

[2]. Liu C, et al. Imazamethabenz inhibits human breast cancer cell proliferation, migration and invasion via combination with Pin1. Mol Med Rep. 2017 May;15(5):3210-3214.  

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
1165.4±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C32H38N6O11

[ Molecular Weight ]:
682.678

[ Flash Point ]:
658.6±34.3 °C

[ Exact Mass ]:
682.259827

[ LogP ]:
2.19

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.619

Related Compounds